软骨细胞培养及其调控
培养大量扩增、分化维持其正常的表型及代谢的调控因素会渐为人们所明晰，为组织工 程化软骨修复软骨缺损、体外培养软骨细胞建立软骨细胞库(永生化软骨细胞)及揭示退变性 骨关节病又开拓了一条新的途径。
参考文献：
〔1〕 Duke.PJ,Daune.EL,Montufor solis.P,studies of chondrogenesis in rotating system［J］.J Cell Biochem 1994 15(3):1～5.
〔2〕 Va canti CA,Cao YL,Neo-cartilage genorated from chondrocyt es isolated from 100 year old human cartilage［J］.Transplant Proc 1994 26(4) 1 069～1 077.
〔3〕 T1.Redi,P.Galera,A.Mauviel,Transforming growth factor β st imulates collagen and glycosaminoglycan biosynthesis in cultured rabbit articula r chondrocytes.FEBs letters 1988 234(172～775).
〔4〕 Karin,Boumedieno,Nathalie,Fielisaz,Cell-cycle-depen-dent expression of transforming growth factor-β type Ⅰ receptor correlations with differential proliferation effects of TGF-β in articular chondrocytes［J］. Exp-cell-Res,1998，243:173～181.
〔5〕 Kato Y.Robet C.Terminal differentiation and clacification i n rabbit chondrocytes culture groun in centrifuge tubes,Regulation by TGF-beta and serum factors,Pro Nat1 Acod sci USA,1988，85:955～961.
〔6〕 Sporn MB Chenp vu.Transforming growth factor-beta biologi cal function and chemical structure［J］.Science,1986,233:532～40.
〔7〕 Qi W.N Scully S.P.extracellular collagen modulats the regul ation of chondrocytes by the TGF-β,J-ORTHOP-rES,1997,15:480～490.
〔8〕 Qi W.N scean.P.Effects of type Ⅱ collagen in chondrocyte r esponse to TGF-β regultion［J］.Exp-cell-Res,1998,241:142～150.
〔9〕 Tommo TsvkAzAkⅠ.ToshIRO VSR
〔10〕 Peter C,Yaeger,Tersel.Synthesis action of transform ing gr owth factor-β and insuline-like growth factor-Ⅰ induces expression of type Ⅱ collagen and aggrecan gene in adult human articular chondrocytes［J］.Exp-c ell-Res,1997,237:318～325.
〔11〕 Firedini,Marrie1.Transforming growth factor-beta e xert op posite effects from interleukin-β on cultured rabbit articular chondrocytes th rough reductioin of interleukin receptor expression［J］.Arthrits & Rheumatism ,1993,36:44～50.
〔12〕 Mordes TI,Robberts AB.Transforming growth factor-b eta reg ulates the metabolism of pretoglcans in bovine cartilage organ cultures［J］. J .Bioc 《软骨细胞培养及其调控(第3页)》
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参考文献：
〔1〕 Duke.PJ,Daune.EL,Montufor solis.P,studies of chondrogenesis in rotating system［J］.J Cell Biochem 1994 15(3):1～5.
〔2〕 Va canti CA,Cao YL,Neo-cartilage genorated from chondrocyt es isolated from 100 year old human cartilage［J］.Transplant Proc 1994 26(4) 1 069～1 077.
〔3〕 T1.Redi,P.Galera,A.Mauviel,Transforming growth factor β st imulates collagen and glycosaminoglycan biosynthesis in cultured rabbit articula r chondrocytes.FEBs letters 1988 234(172～775).
〔4〕 Karin,Boumedieno,Nathalie,Fielisaz,Cell-cycle-depen-dent expression of transforming growth factor-β type Ⅰ receptor correlations with differential proliferation effects of TGF-β in articular chondrocytes［J］. Exp-cell-Res,1998，243:173～181.
〔5〕 Kato Y.Robet C.Terminal differentiation and clacification i n rabbit chondrocytes culture groun in centrifuge tubes,Regulation by TGF-beta and serum factors,Pro Nat1 Acod sci USA,1988，85:955～961.
〔6〕 Sporn MB Chenp vu.Transforming growth factor-beta biologi cal function and chemical structure［J］.Science,1986,233:532～40.
〔7〕 Qi W.N Scully S.P.extracellular collagen modulats the regul ation of chondrocytes by the TGF-β,J-ORTHOP-rES,1997,15:480～490.
〔8〕 Qi W.N scean.P.Effects of type Ⅱ collagen in chondrocyte r esponse to TGF-β regultion［J］.Exp-cell-Res,1998,241:142～150.
〔9〕 Tommo TsvkAzAkⅠ.ToshIRO VSR
,Effect of TGF-β on insuline -like growth factor-Ⅰ autorine/paracrine axis in cultured rat articular chond rocytes［J］.Exp-cell-Res,1994,215:9～16.
〔10〕 Peter C,Yaeger,Tersel.Synthesis action of transform ing gr owth factor-β and insuline-like growth factor-Ⅰ induces expression of type Ⅱ collagen and aggrecan gene in adult human articular chondrocytes［J］.Exp-c ell-Res,1997,237:318～325.
〔11〕 Firedini,Marrie1.Transforming growth factor-beta e xert op posite effects from interleukin-β on cultured rabbit articular chondrocytes th rough reductioin of interleukin receptor expression［J］.Arthrits & Rheumatism ,1993,36:44～50.
〔12〕 Mordes TI,Robberts AB.Transforming growth factor-b eta reg ulates the metabolism of pretoglcans in bovine cartilage organ cultures［J］. J .Bioc 《软骨细胞培养及其调控(第3页)》
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